Abstract | OBJECTIVES: METHODS: RESULTS: CONCLUSIONS: K/BxA(g7) mice recapitulate the same sequence of events occurring in patients with RA, namely an erosive, inflammatory arthritis followed by atherosclerosis. These data suggest that the K/BxA(g7) mouse is a novel system for investigating the interplay between systemic inflammation occurring in RA and the development of atherosclerosis.
|
Authors | Shawn Rose, Mesut Eren, Sheila Murphy, Heng Zhang, Colby Shad Thaxton, Jaime Chowaniec, Emily A Waters, Thomas J Meade, Douglas E Vaughan, Harris Perlman |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 72
Issue 1
Pg. 89-95
(Jan 2013)
ISSN: 1468-2060 [Electronic] England |
PMID | 22736097
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Topics |
- Animals
- Arthritis, Rheumatoid
(complications, genetics, pathology)
- Atherosclerosis
(complications, genetics, pathology)
- Disease Models, Animal
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
|