Abstract | AIM: We studied the changing trend and factors associated with persistent diarrhoea (PD) in under-five children presenting to a large diarrhoeal disease hospital in urban Dhaka, Bangladesh, over the last two decades. METHODS: We used an unmatched case-control design, with a case (persistent diarrhoea; n=944) to control (acute diarrhoea; n=2832) ratio of 1:3 attending the Dhaka Hospital of icddr,b between 1991 and 2010. RESULTS: The proportion of children with PD decreased significantly from 8% in 1991 to 1% in 2010. The proportion of breastfeeding practices, measles vaccination coverage and vitamin A supplementation among 12-59 months old improved from 79% to 85%, 69% to 85% and 26% to 74%, respectively, which were significant. Although the isolation of rotavirus from stool in children with PD and acute diarrhoea increased, the isolation of Shigella spp., and Vibrio cholerae O1 decreased significantly. In a logistic regression analysis, wasting (OR=1.62), use of antibiotic before attending hospital (OR=5.94), absent clinical dehydration (OR=1.53) and bloody/mucoid stool (OR=3.33) were significantly associated with persistent diarrhoea. CONCLUSION: There, thus, is a need to integrate an appropriate and sustainable deterrent strategy to take the benefit of the significant reduction in prevalence as well as risks of PD in such population.
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Authors | Sumon Kumar Das, Abu Syed Golam Faruque, Mohammod Jobayer Chisti, Mohammad Abdul Malek, Mohammed Abdus Salam, David A Sack |
Journal | Acta paediatrica (Oslo, Norway : 1992)
(Acta Paediatr)
Vol. 101
Issue 10
Pg. e452-7
(Oct 2012)
ISSN: 1651-2227 [Electronic] Norway |
PMID | 22734659
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica. |
Chemical References |
- Anti-Infective Agents
- Measles Vaccine
- Vitamin A
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Topics |
- Anti-Infective Agents
(administration & dosage)
- Bangladesh
(epidemiology)
- Breast Feeding
(trends)
- Case-Control Studies
- Child, Preschool
- Diarrhea
(epidemiology, microbiology)
- Feces
(microbiology)
- Female
- Humans
- Infant
- Interviews as Topic
- Logistic Models
- Male
- Measles Vaccine
(therapeutic use)
- Prevalence
- Risk Assessment
- Rotavirus
(isolation & purification)
- Shigella
(isolation & purification)
- Thinness
(epidemiology)
- Vibrio cholerae O1
(isolation & purification)
- Vitamin A
(administration & dosage)
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