HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Crystal structures, interactions with biomacromolecules and anticancer activities of Mn(II), Ni(II), Cu(II) complexes of demethylcantharate and 2-aminopyridine.

Abstract
Three novel transition metal complexes (Hapy)(2)[M(DCA)(2)]·6H(2)O (M = Mn(II) (1), Ni(II) (2), Cu(II) (3); DCA = demethylcantharate, 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate, C(8)H(8)O(5); Hapy = 2-aminopyridine acid, C(5)H(7)N(2)) were synthesized and characterized by elemental analysis, infrared spectra, thermogravimetric analysis and X-ray diffraction. DNA binding properties of the complexes were investigated by electronic absorption spectra, fluorescence spectra and viscosity measurements. Results indicated the complexes could bind to DNA through partial intercalation mode with binding constants K ( b )/(L·mol(-1)) of 1.91 × 10(4) (1), 5.13 × 10(4) (2) and 1.12 × 10(5) (3) at 298 K. Meanwhile, the interactions of the complexes with BSA were also studied by fluorescence spectra. The results suggested that the complexes could quench the fluorescence of BSA through static quenching with the binding constants K ( A )/(L·mol(-1)) of 1.44 × 10(6) (1), 1.14 × 10(7) (2) and 2.98 × 10(4) (3). And the main contribution was tryptophan residues of BSA. The antiproliferative activity test revealed that complexes showed more intense inhibition ratios against human hepatoma cells lines and human gastric cancer cells lines in vitro. Copper(II) complex (3) possesses the strongest inhibition ratio against human hepatoma cells.
AuthorsFan Zhang, Qiu-Yue Lin, Xiao-Liang Zheng, Ling-Ling Zhang, Qiong Yang, Jia-Ying Gu
JournalJournal of fluorescence (J Fluoresc) Vol. 22 Issue 5 Pg. 1395-406 (Sep 2012) ISSN: 1573-4994 [Electronic] Netherlands
PMID22733190 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aminopyridines
  • Antineoplastic Agents
  • Organometallic Compounds
  • demethylcantharidin
  • Serum Albumin, Bovine
  • Manganese
  • Copper
  • Nickel
  • Cantharidin
  • alpha-aminopyridine
Topics
  • Aminopyridines (chemistry)
  • Antineoplastic Agents (chemistry, metabolism, pharmacology)
  • Binding Sites
  • Cantharidin (analogs & derivatives, chemistry)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Copper (chemistry)
  • Crystallography, X-Ray
  • Humans
  • Manganese (chemistry)
  • Nickel (chemistry)
  • Organometallic Compounds (chemistry, metabolism, pharmacology)
  • Protein Binding
  • Serum Albumin, Bovine (metabolism)
  • Spectrum Analysis
  • Viscosity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: