Abstract |
Autoantibodies against several aminoacyl- transfer-RNA synthetases have been described in patients with myositis; anti- threonyl-tRNA synthetase (anti-PL-7) is one of the rarest. We describe the clinical and laboratory characteristics of a cohort of European anti-PL-7 patients, and compare them with previously reported cases. This multicenter study of patients positive for anti-PL-7, identified between 1984 and 2011, derives from the EUMYONET cohort. Clinical and serologic data were obtained by retrospective laboratory and medical record review, and statistical analyses were performed with chi-squared and Fisher exact tests. Eighteen patients, 15 women, were anti-PL-7 antibody positive. Median follow-up was 5.25 years (interquartile range, 2.8-10.7 yr), and 4 patients died. All patients had myositis (12 polymyositis, 5 dermatomyositis, and 1 amyopathic dermatomyositis), 10 (55.6%) had interstitial lung disease, and 9 (50%) had pericardial effusion. Occupational exposure to organic/inorganic particles was more frequent in patients with interstitial lung disease than in the remaining patients (5 of 10 vs. 1 of 7; p = 0.152), although the difference was not significant. Concurrent autoantibodies against Ro60 and Ro52 were seen in 8 of 14 (57%) patients studied. In the literature review the most common manifestations of anti-PL-7 antisynthetase syndrome were interstitial lung disease (77%), myositis (75%), and arthritis (56%). As in other subsets of the antisynthetase syndrome, myositis and interstitial lung disease are common features of the anti-PL-7 antisynthetase syndrome. In addition, we can add pericarditis as a possible manifestation related to anti-PL-7 antibodies.
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Authors | Ane Labirua-Iturburu, Albert Selva-O'Callaghan, Melinda Vincze, Katalin Dankó, Jiri Vencovsky, Benjamin Fisher, Peter Charles, Maryam Dastmalchi, Ingrid E Lundberg |
Journal | Medicine
(Medicine (Baltimore))
Vol. 91
Issue 4
Pg. 206-211
(Jul 2012)
ISSN: 1536-5964 [Electronic] United States |
PMID | 22732951
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antibodies, Antinuclear
- Autoantibodies
- Threonine-tRNA Ligase
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Topics |
- Adult
- Antibodies, Antinuclear
(analysis, immunology)
- Autoantibodies
(analysis, immunology)
- Cohort Studies
- Combined Modality Therapy
- Dermatomyositis
(epidemiology, immunology)
- Europe
(epidemiology)
- Female
- Humans
- Incidence
- Lung Diseases, Interstitial
(epidemiology, immunology)
- Male
- Middle Aged
- Myositis
(diagnosis, epidemiology, immunology, therapy)
- Polymyositis
(epidemiology, immunology)
- Prognosis
- Retrospective Studies
- Risk Assessment
- Severity of Illness Index
- Survival Analysis
- Threonine-tRNA Ligase
(immunology, metabolism)
- Treatment Failure
- Treatment Outcome
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