Acute water intoxication after intranasal desmopressin in a patient with primary polydispsia.

Abstract

Only a few cases of severe acute water intoxication (AWI) due to intranasal desmopressin have been reported, none of which occurred in patients with primary polydipsia. We describe a case of AWI with semicoma and convulsions, due to intranasal desmopressin, in a 32-year-old patient with dipsogenic diabetes insipidus. Previous reported cases of AWI due to desmopressin are discussed. The importance of ruling out primary polydipsia when this drug is used, not only for central diabetes insipidus but also for other current indications such as classic hemophilia, is stressed.

• Authors: J Ferrer, I Halperin, J I Conget, J Cabrer, E Esmatjes, E Vilardell
• Journal: Journal of endocrinological investigation (J Endocrinol Invest) Vol. 13 Issue 8 Pg. 663-6 (Sep 1990) ISSN: 0391-4097 [Print] Italy
• PMID: 2273207 (Publication Type: Case Reports, Journal Article)

Chemical References

• Deamino Arginine Vasopressin

Topics

• Administration, Intranasal
• Adult
• Deamino Arginine Vasopressin (administration & dosage, adverse effects, therapeutic use)
• Drinking (drug effects)
• Female
• Humans
• Polyuria (complications, drug therapy)
• Water Intoxication (etiology)