Abstract | OBJECTIVE: METHOD:
VEGF and its receptor (flk-1), expression were examined by immunohistochemistry using LSAB method in sections of NIP from 48 patients and squamous carcinoma from 8 patients. RESULT: All the epithelium together with the adjacent vascular and stroma,expressed increased positive staining of VEGF and flk-1 with the degree of atypical hyperplasia in epithelium. The VEGF/flk-1 expression in epithelium was significantly stronger in severe atypical hyperplasia than that in mild atypical hyperplasia, and same in mild atypical hyperplasia than in NIPs (P<0.01). CONCLUSION:
VEGF/flk-1 participate in the growth of NIPs. The enhanced VEGF/flk-1 in the epithelium may be identified as one of the parameters in judging malignant transformation of NIPs.
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Authors | Hui Kong, Qingjie Guan, Xiuzhen Sun, Naiyu Wang |
Journal | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
(Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi)
Vol. 26
Issue 8
Pg. 337-8, 342
(Apr 2012)
ISSN: 2096-7993 [Print] China |
PMID | 22730813
(Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factor Receptor-2
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Topics |
- Aged
- Carcinoma, Squamous Cell
(genetics, metabolism, pathology)
- Female
- Humans
- Male
- Middle Aged
- Nose Neoplasms
(genetics, metabolism, pathology)
- Papilloma, Inverted
(genetics, metabolism, pathology)
- Prognosis
- Vascular Endothelial Growth Factor A
(genetics, metabolism)
- Vascular Endothelial Growth Factor Receptor-2
(genetics, metabolism)
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