[Study on the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage].

Abstract

OBJECTIVE:

To study the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage.

METHODS:

Choose 34 confirmed pneumoconiosis patients as drug treatment group and complex treatment group, and 17 tested workers as control group. Collected the content of TGF-beta1 and P III P which in these three investigated groups.

RESULTS:

Drug treatment group and complex treatment group of patients improved the clinical symptoms and lung function Compared with Pretreatment, the FVC, FEV1.0, FEV1.0/FVC, MVV was obviously higher than those before treatment (P < 0.05). Complex treatment group than in the drug treatment group increased more significantly (P < 0.05). The level of TGF-beta1 and P III P was reduced after complex treatment (P < 0.05). Moreover,the level of TGF-beta1 and P III P in these patients are lower than in those patients treated with tetrandrine combined with whole lung lavage (P < 0.05).

CONCLUSION:

Tetrandrine combined with whole-lung lavage could significantly retard the development of pneumoconiosis by lessening the TGF-beta1 and P III P in serum.

• Authors: Li-Jun Peng, Qi-Shang Zhu
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 30 Issue 1 Pg. 68-70 (Jan 2012) ISSN: 1001-9391 [Print] China
• PMID: 22730694 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Benzylisoquinolines
• Collagen Type III
• Transforming Growth Factor beta1
• tetrandrine

Topics

• Adult
• Benzylisoquinolines (therapeutic use)
• Bronchoalveolar Lavage
• Collagen Type III (blood)
• Combined Modality Therapy
• Humans
• Male
• Middle Aged
• Pneumoconiosis (blood, therapy)
• Transforming Growth Factor beta1 (blood)
• Treatment Outcome