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Quinacrine induced mood disturbance--the unmasking of bipolar affective disorder.

Abstract
The authors report the case of a 20-year-old man who presented with a de novo episode of hypomania subsequent to the initiation of quinacrine for treatment resistant giardiasis. The hypomanic episode commenced some 20 days after the successful completion of a week long course of quinacrine 100 mg three times daily. The hypomanic episode was treated with olanzapine 10 mg daily. Two months subsequent to this, the patient developed a moderate depressive episode which was treated with escitalopram and olanzapine. One month after the resolution of the depressive episode, he once again presented with a hypomanic episode. The recurring episodes of discrete mood disturbance all occurred within 5 months of the commencement of quinacrine in an individual with no personal history of affective disorders.
AuthorsJohn Lally, Fintan Byrne, Elizabeth Walsh
JournalBMJ case reports (BMJ Case Rep) Vol. 2012 (Jun 21 2012) ISSN: 1757-790X [Electronic] England
PMID22729334 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiprotozoal Agents
  • Quinacrine
Topics
  • Adult
  • Antiprotozoal Agents (adverse effects)
  • Bipolar Disorder (chemically induced, diagnosis, drug therapy)
  • Giardiasis (drug therapy)
  • Humans
  • Male
  • Quinacrine (adverse effects)
  • Young Adult

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