Efficacy of tiamulin against experimentally induced Streptococcus suis type-2 infection in swine.

Abstract

Eighteen 4-week-old pigs were used in a study to evaluate tiamulin in drinking water for control of experimentally induced Streptococcus suis type-2 infection. Pigs in groups A and B (n = 6 pigs/group) were aerosolized with a logarithmic-growth phase culture of S suis type 2, whereas pigs in group C (n = 6 pigs) served as noninfected and nonmedicated controls. After exposure to S suis, pigs in group B were given 180 mg of tiamulin/L of drinking water for 5 days. Pigs in group B consumed more feed (P = 0.009) and gained body weight faster (P = 0.02) than did pigs in group A. Pigs in group A had higher rectal temperature (P = 0.05) for up to 7 days after S suis exposure, higher clinical sign scores (P = 0.008), higher serum cortisol concentration on days 7 and 14, higher gross lesion scores (P = 0.03), and higher microscopic lesion scores (P = 0.01) than did pigs in groups B and C. Gross and microscopic lesions in pigs of groups A and B included meningitis, pneumonia, pleuritis, pericarditis, peritonitis, and synovitis of variable severity. Streptococcus suis type 2 was recovered from tissue specimens of 2 group-A pigs and 1 group-B pig. Data indicated that tiamulin administered via drinking water significantly reduced the effects of S suis type-2 infection.

• Authors: M M Chengappa, L W Pace, J A Williams, C H Herren, S E Ascher
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 197 Issue 11 Pg. 1467-70 (Dec 01 1990) ISSN: 0003-1488 [Print] United States
• PMID: 2272877 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Diterpenes
• tiamulin

Topics

• Administration, Oral
• Animals
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Body Temperature
• Diterpenes (administration & dosage, therapeutic use)
• Drinking
• Eating (drug effects)
• Streptococcal Infections (drug therapy, prevention & control, veterinary)
• Swine
• Swine Diseases (drug therapy, prevention & control)
• Weight Gain (drug effects)