Abstract | BACKGROUND: METHODS: RESULTS: Our results demonstrated that myrtenal exhibits strong antioxidant property in all the in vitro assays and the in vivo results revealed that the antioxidant status was significantly decreased in hepatoma bearing animals. The expression of anti-apoptotic proteins was up regulated and in contrast the apoptotic protein was down regulated in hepatoma bearing animals. Treatment with myrtenal to cancer bearing animals resulted in remarkable increase in the inherent antioxidants and excellent modulation in the proteins of apoptotic and anti-apoptotic cascade. Further, the RT-PCR analysis of protein expressions and histological analysis of liver tissues inevitably confirms the anticancer property of myrtenal. CONCLUSIONS: It is concluded that myrtenal exhibits excellent free radical scavenging activity and anticancer activity through the suppression of hepatocellular carcinoma in wistar rats. Thereby giving a positive insight to take this compound as an effective therapeutic agent against hepatoma.
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Authors | Lingaiah Hari Babu, Srinivasan Perumal, Maruthaiveeran Periyasamy Balasubramanian |
Journal | Cellular oncology (Dordrecht)
(Cell Oncol (Dordr))
Vol. 35
Issue 4
Pg. 269-83
(Aug 2012)
ISSN: 2211-3436 [Electronic] Netherlands |
PMID | 22722977
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Benzothiazoles
- Bicyclic Monoterpenes
- Biphenyl Compounds
- Free Radical Scavengers
- Picrates
- Sulfonic Acids
- Terpenes
- bcl-2-Associated X Protein
- Superoxides
- 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
- Nitric Oxide
- Hydroxyl Radical
- Diethylnitrosamine
- myrtenal
- 1,1-diphenyl-2-picrylhydrazyl
- Catalase
- Superoxide Dismutase
- Caspase 3
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Topics |
- Animals
- Antioxidants
(metabolism, pharmacology)
- Apoptosis
(drug effects, genetics)
- Benzothiazoles
(antagonists & inhibitors, chemistry, metabolism)
- Bicyclic Monoterpenes
- Biphenyl Compounds
(antagonists & inhibitors, chemistry, metabolism)
- Blotting, Western
- Caspase 3
(genetics, metabolism)
- Catalase
(metabolism)
- Diethylnitrosamine
- Dose-Response Relationship, Drug
- Free Radical Scavengers
(pharmacology)
- Gene Expression
(drug effects)
- Hydroxyl Radical
(antagonists & inhibitors, metabolism)
- Liver
(drug effects, metabolism, pathology)
- Liver Neoplasms, Experimental
(chemically induced, drug therapy, genetics)
- Male
- Nitric Oxide
(antagonists & inhibitors, metabolism)
- Picrates
(antagonists & inhibitors, chemistry, metabolism)
- Rats
- Rats, Wistar
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction
(drug effects, genetics)
- Sulfonic Acids
(antagonists & inhibitors, chemistry, metabolism)
- Superoxide Dismutase
(metabolism)
- Superoxides
(antagonists & inhibitors, metabolism)
- Terpenes
(pharmacology)
- bcl-2-Associated X Protein
(genetics, metabolism)
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