Abstract |
The area postrema is one of the circumventricular organs, lacks a blood-brain barrier, and is well known as the chemoreceptor trigger zone for emesis. Area postrema neurons are sensitive to emetic chemical substances carried in the blood plasma. Our previous study demonstrated the presence of 3 types of neurons characterized by different ion channels expressed in each cell type, but the type or types of area postrema neurons involved in the induction of nausea and/or emesis have remained unclear. To clarify the role of the most populous cells, which express the hyperpolarization-activated cation channel (H-channel), in induction of nausea and/or emesis, we investigated the effects of ZD7288 (an H-channel inhibitor) on apomorphine-induced conditioned taste aversion (CTA) to saccharin and c-Fos expression in the area postrema. We found that ZD7288 inhibited the acquisition of CTA and reduced apomorphine-induced c-Fos expression in the area postrema, indicating the involvement of the cells expressing H-channels in the induction of nausea and/or emesis. Finally, we discuss the role of cells expressing H-channels in the mechanism of nausea and/or vomiting.
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Authors | Keisuke Shinpo, Yoshiyuki Hirai, Hitoshi Maezawa, Yasunori Totsuka, Makoto Funahashi |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 107
Issue 1
Pg. 98-103
(Aug 20 2012)
ISSN: 1873-507X [Electronic] United States |
PMID | 22722099
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Cyclic Nucleotide-Gated Cation Channels
- Dopamine Agonists
- Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
- Potassium Channels
- Proto-Oncogene Proteins c-fos
- Pyrimidines
- ICI D2788
- Apomorphine
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Topics |
- Analysis of Variance
- Animals
- Apomorphine
(adverse effects)
- Area Postrema
(pathology)
- Avoidance Learning
(drug effects)
- Conditioning, Classical
(physiology)
- Cyclic Nucleotide-Gated Cation Channels
(metabolism)
- Dopamine Agonists
(pharmacology)
- Dose-Response Relationship, Drug
- Drinking Behavior
(drug effects)
- Feeding Behavior
(drug effects)
- Food Preferences
(drug effects)
- Gene Expression Regulation
(drug effects, physiology)
- Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
- Nausea
(chemically induced, pathology)
- Neurons
(metabolism)
- Potassium Channels
(metabolism)
- Proto-Oncogene Proteins c-fos
(metabolism)
- Pyrimidines
(adverse effects)
- Rats
- Rats, Wistar
- Taste
(drug effects, physiology)
- Vomiting
(chemically induced, pathology)
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