Abstract | INTRODUCTION AND OBJECTIVES: Paraoxonases may exert anti-atherogenic action by reducing lipid peroxidation. Previous studies examined associations between polymorphisms in the paraoxonase 1 (PON1) gene and development of coronary artery disease (CAD), with inconsistent results. Given the similarities in clinical and pathophysiological risk factors of CAD and calcific aortic valve stenosis (CAVS), we postulated a link between PON1 alleles and CAVS progression. METHODS: We investigated the association between PON1 55 and 192 single nucleotide polymorphisms (SNPs), their enzyme activity, and CAVS progression assessed by aortic valve area and transvalvular peak velocity in 67 consecutive patients with moderate CAVS and 251 healthy controls. RESULTS: CONCLUSION: The PON1 genotype Q192R SNP has an important effect on CAVS disease progression. This study helps outline a genotype-phenotype relationship for PON1 in this unique population.
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Authors | Luis M Moura, Susana Faria, Miguel Brito, Fausto J Pinto, Steen D Kristensen, Isabel M Barros, Nalini Rajamannan, Francisco Rocha-Gonçalves |
Journal | American journal of cardiovascular disease
(Am J Cardiovasc Dis)
Vol. 2
Issue 2
Pg. 123-32
( 2012)
ISSN: 2160-200X [Electronic] United States |
PMID | 22720202
(Publication Type: Journal Article)
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