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Peripheral neuropathy and myopathy. An experimental study of rats on alcohol and variable dietary thiamine.

Abstract
The effects of variable dietary thiamine concentrations (deficient, normal, surplus) on the development of alcoholic neuromyopathy in rats exposed for 36 weeks to 10-25% (v/v) ethanol or water (control group) as the sole drinking fluid were studied by histological and electrophysiological methods. Abnormalities in the structure of the sciatic nerve (phagocytosis, myelin abnormalities, increase in nonspecific cholinesterase activity) and tibial muscles (angular atrophic fibers, group atrophy, fibre necrosis) developed more frequently in animals on diets deficient in thiamine than in animals on diets with normal or surplus thiamine, and more frequently in animals drinking alcohol and water than in those drinking water alone. No differences were observed between the different groups in the number of perivascular sympathetic nerves, in the motor nerve conduction velocities and in the muscle fibrillation potentials. Thus, thiamine deficiency, established as a significant reduction of red blood cell transketolase activity, seems to have a deleterious effect on the peripheral nerves and muscles. The effect is enhanced by the simultaneous consumption of ethyl alcohol.
AuthorsJ Juntunen, H Teräväinen, K Eriksson, A Larsen, M Hillbom
JournalVirchows Archiv. A, Pathological anatomy and histology (Virchows Arch A Pathol Anat Histol) Vol. 383 Issue 3 Pg. 241-52 (Aug 23 1979) ISSN: 0340-1227 [Print] Germany
PMID227154 (Publication Type: Journal Article)
Topics
  • Alcoholism (complications)
  • Animals
  • Humans
  • Muscular Atrophy (etiology)
  • Muscular Diseases (etiology, pathology)
  • Neural Conduction
  • Neuromuscular Diseases (complications, pathology)
  • Peripheral Nervous System Diseases (etiology, pathology)
  • Phagocytosis
  • Rats
  • Sciatic Nerve (pathology)
  • Thiamine Deficiency (complications, pathology)

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