Immunohistochemical study of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 in the hippocampal vasculature: pathological synergy of Alzheimer's disease and diabetes mellitus.

Abstract

Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) is involved in vascular endothelial damage as well as in the vascular degeneration underlying diabetes mellitus and Alzheimer's disease (AD). Recent evidence suggests that classic pathological features of AD are more pronounced in diabetic mellitus patients. To investigate the expression and distribution of SSAO/VAP-1 in the two pathologies, we have performed an immunohistochemical study in human hippocampal vessels of AD, AD with diabetic mellitus (ADD), diabetic mellitus (DM), and nondemented (ND) patients. The present results demonstrate major vessel accumulation of both SSAO/VAP-1 and amyloid-β immunolabeling intensity in ADD compared with AD patients. Interestingly, nearly damaged vessels with high levels of SSAO/VAP-1 also showed increased oxidative damage markers (AGE, RAGE, and SOD-1) and glial activation (GFAP and HLA). Overall, this work suggests that high vascular SSAO/VAP-1 levels in human hippocampus may contribute to vascular degeneration, which can explain the severe progression in patients with both pathologies.

• Authors: Tony Valente, Alejandro Gella, Montse Solé, Núria Durany, Mercedes Unzeta
• Journal: Journal of neuroscience research (J Neurosci Res) Vol. 90 Issue 10 Pg. 1989-96 (Oct 2012) ISSN: 1097-4547 [Electronic] United States
• PMID: 22714978 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Wiley Periodicals, Inc.

Chemical References

• Amyloid beta-Peptides
• Glial Fibrillary Acidic Protein
• Glycation End Products, Advanced
• HLA Antigens
• SOD1 protein, human
• Vascular Cell Adhesion Molecule-1
• tau Proteins
• Superoxide Dismutase
• Superoxide Dismutase-1
• Amine Oxidase (Copper-Containing)

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (complications, metabolism, pathology)
• Amine Oxidase (Copper-Containing) (analysis, metabolism)
• Amyloid beta-Peptides (metabolism)
• Blood Vessels (metabolism)
• Cerebrovascular Circulation (physiology)
• Diabetes Complications (metabolism, pathology)
• Diabetes Mellitus (metabolism, pathology)
• Female
• Glial Fibrillary Acidic Protein (metabolism)
• Glycation End Products, Advanced (metabolism)
• HLA Antigens (metabolism)
• Hippocampus (blood supply, metabolism)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Neuroglia (physiology)
• Oxidative Stress (physiology)
• Plaque, Amyloid (pathology)
• Superoxide Dismutase (metabolism)
• Superoxide Dismutase-1
• Vascular Cell Adhesion Molecule-1 (analysis, metabolism)
• tau Proteins (metabolism)