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Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

Abstract
Several studies have successfully employed GM1 ganglioside to treat animal models of Parkinson's disease (PD), suggesting involvement of this ganglioside in PD etiology. We recently demonstrated that genetically engineered mice (B4galnt1(-/-) ) devoid of GM1 acquire characteristic symptoms of this disorder, including motor impairment, depletion of striatal dopamine, selective loss of tyrosine hydroxylase-expressing neurons, and aggregation of α-synuclein. The present study demonstrates similar symptoms in heterozygous mice (HTs) that express only partial GM1 deficiency. Symptoms were alleviated by administration of L-dopa or LIGA-20, a membrane-permeable analog of GM1 that penetrates the blood-brain barrier and accesses intracellular compartments. Immunohistochemical analysis of paraffin sections from PD patients revealed significant GM1 deficiency in nigral dopaminergic neurons compared with age-matched controls. This was comparable to the GM1 deficiency of HT mice and suggests that GM1 deficiency may be a contributing factor to idiopathic PD. We propose that HT mice with partial GM1 deficiency constitute an especially useful model for PD, reflecting the actual pathophysiology of this disorder. The results point to membrane-permeable analogs of GM1 as holding promise as a form of GM1 replacement therapy.
AuthorsGusheng Wu, Zi-Hua Lu, Neil Kulkarni, Robert W Ledeen
JournalJournal of neuroscience research (J Neurosci Res) Vol. 90 Issue 10 Pg. 1997-2008 (Oct 2012) ISSN: 1097-4547 [Electronic] United States
PMID22714832 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2012 Wiley Periodicals, Inc.
Chemical References
  • Antiparkinson Agents
  • Gangliosides
  • Synucleins
  • 3,4-Dihydroxyphenylacetic Acid
  • G(M1) Ganglioside
  • Levodopa
  • Tyrosine 3-Monooxygenase
  • N-Acetylgalactosaminyltransferases
  • polypeptide N-acetylgalactosaminyltransferase
  • Dopamine
Topics
  • 3,4-Dihydroxyphenylacetic Acid (analysis, metabolism)
  • Aged
  • Aged, 80 and over
  • Aging (physiology)
  • Animals
  • Antiparkinson Agents (pharmacology)
  • Blotting, Western
  • Cell Count
  • Dopamine (analysis, metabolism)
  • Dopaminergic Neurons (physiology)
  • Female
  • G(M1) Ganglioside (deficiency, genetics, therapeutic use)
  • Gangliosides (metabolism)
  • Humans
  • Immunohistochemistry
  • Levodopa (pharmacology)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • N-Acetylgalactosaminyltransferases (genetics)
  • Parkinson Disease (genetics, pathology)
  • Synucleins (metabolism)
  • Tyrosine 3-Monooxygenase (metabolism)

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