Abstract | PURPOSE: METHODS: RESULTS: The median follow-up period was 16.0 months. The 1-year and 3-year survival rates were 56% and 14%, respectively. The median progression-free survival (PFS) and overall survival (OS) time was 9.8 and 13.3 months respectively. There was no statistical significance of the PFS of the two groups. The OS (median 16.3 months) in the R-TP group was superior to that in the R-FP group (median: 9.8 months) (p = 0.012). Among the patients who had received ≥60 Gy irradiation dose, the median PFS (10.6 months) and OS (16.3 months) were significantly superior to the PFS (8.7 months) and OS (11.3 months) among those patients did not (all p < 0.05). Grade 3 treatment-related gastritis were observed in 6 (27.3%) and 7 (25%) patients in the R-FP and R-TP group respectively. By univariate survival analysis, the age (<60 years), TP regimen and higher irradiation dose might improve the OS of such patients in present study. CONCLUSIONS: For those patients with post-operative loco-recurrent squamous-cell esophageal carcinoma, radiotherapy combined with either FP or TP regimen chemotherapy was an effective salvage treatment. Younger age, treatment with the TP regimen and an irradiation dose ≥60 Gy might improve the patients' treatment outcome.
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Authors | Jian Zhang, Feng Peng, Na Li, Yongmei Liu, Yong Xu, Lin Zhou, Jin Wang, Jiang Zhu, Meijuan Huang, Youling Gong |
Journal | Radiation oncology (London, England)
(Radiat Oncol)
Vol. 7
Pg. 93
(Jun 19 2012)
ISSN: 1748-717X [Electronic] England |
PMID | 22713587
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Paclitaxel
- Cisplatin
- Fluorouracil
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Topics |
- Adult
- Antineoplastic Agents
(administration & dosage)
- Carcinoma, Squamous Cell
(therapy)
- Chemoradiotherapy
- Cisplatin
(administration & dosage)
- Disease-Free Survival
- Esophageal Neoplasms
(therapy)
- Esophagectomy
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(therapy)
- Paclitaxel
(administration & dosage)
- Retrospective Studies
- Salvage Therapy
(methods)
- Treatment Outcome
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