Abstract | AIMS: METHODS AND RESULTS: In this study, we used the atherosclerosis prone Ldlr-/- mice, and cell culture experiments to evaluate the role of 3-HAA in atherosclerosis. Eight weeks treatment with 3-HAA significantly reduced the lesion size in the aorta, and modulated local and systemic inflammatory responses. 3-hydroxyanthranilic acid inhibited the uptake of oxLDL by macrophages, an initiating event in the formation of foam cells, a major cellular component of atherosclerotic lesions. Surprisingly, 3-HAA significantly affected plasma cholesterol and triglyceride levels in Ldlr-/- mice, likely due to modulation of signalling through peroxisome proliferator-activated receptors. CONCLUSION:
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Authors | Lei Zhang, Olga Ovchinnikova, Andreas Jönsson, Anna M Lundberg, Martin Berg, Göran K Hansson, Daniel F J Ketelhuth |
Journal | European heart journal
(Eur Heart J)
Vol. 33
Issue 16
Pg. 2025-34
(Aug 2012)
ISSN: 1522-9645 [Electronic] England |
PMID | 22711758
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Free Radical Scavengers
- Hypolipidemic Agents
- Indoleamine-Pyrrole 2,3,-Dioxygenase
- Lipoproteins, LDL
- RNA, Messenger
- oxidized low density lipoprotein
- 3-Hydroxyanthranilic Acid
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Topics |
- 3-Hydroxyanthranilic Acid
(pharmacology)
- Animals
- Atherosclerosis
(immunology, prevention & control)
- Diet, High-Fat
- Free Radical Scavengers
(pharmacology)
- Hypercholesterolemia
(immunology, prevention & control)
- Hypolipidemic Agents
(pharmacology)
- Immunity, Cellular
(drug effects)
- Immunohistochemistry
- Indoleamine-Pyrrole 2,3,-Dioxygenase
(metabolism)
- Lipoproteins, LDL
(drug effects, metabolism)
- Macrophages
(drug effects, metabolism)
- Mice
- Mice, Inbred Strains
- RNA, Messenger
(metabolism)
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