Proteome of Coxiella burnetii.

Abstract

Recent proteomic studies of C. burnetii, the etiological agent of Q fever, have brought a deeper insight into the pathogen's physiology and offered new possibilities in investigations of inter- or intra-species relatedness. The data generated from these studies in conjunction with the current genomic sequence databases may reveal additional identities for conserved and unique C. burnetii biomarkers and aid in creating algorithms and/or databases that could develop into diagnostic and detection tools for the pathogen. Moreover, wide scale screening and further characterization of potential C. burnetii protein antigens along with a comprehensive evaluation of the humoral immune response will be of fundamental importance towards research and development of a safe and efficacious vaccine as well as improved serodiagnostic tests for rapid and sensitive detection of the Q fever pathogen. Given these advances, proteomics may make marked contributions to the improvement of human health protection against C. burnetii in the coming years.

• Authors: Robert Ihnatko, Edward Shaw, Rudolf Toman
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 984 Pg. 105-30 ( 2012) ISSN: 0065-2598 [Print] United States
• PMID: 22711629 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antigens, Bacterial
• Biomarkers
• Proteome

Topics

• Antigens, Bacterial (genetics, immunology, metabolism)
• Biomarkers (metabolism)
• Coxiella burnetii (genetics, immunology, metabolism)
• Humans
• Immunity, Humoral (genetics, immunology)
• Proteome (genetics, immunology, metabolism)
• Q Fever (genetics, immunology, metabolism, microbiology)