Abstract | BACKGROUND: METHODS: Clinicopathological data and tissue samples were collected from stage II (n = 226) and stage III (n = 160) colon cancer patients. Tissue microarrays were constructed with cores taken from both the center and the periphery of the tumor. These were immunohistochemically stained for lumican and versican. Expression levels were scored on digitized slides. Statistical evaluation was performed. RESULTS:
Versican expression by epithelial cells in the periphery of the tumor, i.e., near the invasive front, was correlated to a longer disease-free survival for the whole cohort (P = 0.01), stage III patients only (P = 0.01), stage III patients with microsatellite-instable tumors (P = 0.04), and stage III patients with microsatellite-stable tumors who did not receive adjuvant chemotherapy (P = 0.006). Lumican expression in epithelial cells overall in the tumor was correlated to a longer disease-specific survival in stage II patients (P = 0.05) and to a longer disease-free survival and disease-specific survival in microsatellite-stable stage II patients (P = 0.02 and P = 0.004). CONCLUSIONS:
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Authors | Meike de Wit, Eric J Th Belt, Pien M Delis-van Diemen, Beatriz Carvalho, Veerle M H Coupé, Hein B A C Stockmann, Herman Bril, Jeroen A M Beliën, Remond J A Fijneman, Gerrit A Meijer |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 20 Suppl 3
Pg. S348-59
(Dec 2013)
ISSN: 1534-4681 [Electronic] United States |
PMID | 22711178
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Chondroitin Sulfate Proteoglycans
- LUM protein, human
- Lumican
- Versicans
- Keratan Sulfate
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Chondroitin Sulfate Proteoglycans
(metabolism)
- Colonic Neoplasms
(metabolism, mortality, pathology)
- Epithelial Cells
(metabolism)
- Female
- Follow-Up Studies
- Humans
- Immunoenzyme Techniques
- Keratan Sulfate
(metabolism)
- Lumican
- Male
- Microsatellite Repeats
- Middle Aged
- Neoplasm Grading
- Neoplasm Recurrence, Local
(metabolism, mortality, pathology)
- Neoplasm Staging
- Prognosis
- Stromal Cells
(metabolism)
- Survival Rate
- Tissue Array Analysis
- Versicans
(metabolism)
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