[Headache following intrathecal therapy in acute leukemia: trial of tiapride as a symptomatic treatment (author's transl)].

Abstract

11 patients experienced 40 intrathecal injections of cytotoxic drugs during the treatment of acute leukemia. Tiapride was used as a preventive or curative therapy for headache. Results were found excellent or good in 70% of cases. Frequency and intensity of headache were reduced by half. Tiapride seems more effective in early headache than in cephalalgia occuring later.

• Authors: A A Audebert, D Zylberait, M Krulik, J Debray
• Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris (Sem Hop) 1979 May 18-25 Vol. 55 Issue 19-20 Pg. 993-7 France
• Vernacular Title: Traitement des céphalées secondaires à l'injection intra-rachidienne d'antimitotiques.
• PMID: 227100 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Benzamides
• Cytarabine
• Tiapamil Hydrochloride
• Methotrexate

Topics

• Adult
• Aged
• Antimetabolites, Antineoplastic (administration & dosage)
• Benzamides (therapeutic use)
• Cytarabine (administration & dosage, adverse effects)
• Female
• Headache (drug therapy, etiology, prevention & control)
• Humans
• Injections, Spinal
• Leukemia (drug therapy)
• Male
• Meningeal Neoplasms (drug therapy)
• Methotrexate (administration & dosage, adverse effects)
• Middle Aged
• Tiapamil Hydrochloride (therapeutic use)