[Effect of delta-sleep inducing peptide on the functional activity of some organs and tissues of rats during physiological aging].

Abstract

The authors show that exogenous delta-sleep inducing peptide (DSIP) injected subcutaneously to the rats in the age of 2-24 months of postnatal development in a dose of 100 mg/kg of animal body weight in courses for 5 consecutive days every month, has a hepatoprotective effect. DSIP does not affect the functional activity of the pancreas, and is not involved in the regulation of calcium homeostasis in the physiological aging of the organism.

• Authors: T I Bondarenko, E A Maĭboroda, I I Mikhaleva, I A Prudchenko
• Journal: Advances in gerontology = Uspekhi gerontologii (Adv Gerontol) Vol. 25 Issue 1 Pg. 132-8 ( 2012) ISSN: 1561-9125 [Print] Russia (Federation)
• PMID: 22708458 (Publication Type: English Abstract, Journal Article)

Chemical References

• Delta Sleep-Inducing Peptide
• Calcium

Topics

• Aging (drug effects, physiology)
• Animals
• Calcium (blood)
• Delta Sleep-Inducing Peptide (pharmacology)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Injections, Subcutaneous
• Liver (drug effects, physiology)
• Liver Function Tests
• Male
• Pancreas (drug effects, physiology)
• Pancreatic Function Tests
• Rats
• Treatment Outcome