Abstract | STUDY DESIGN: We performed a multicentric, randomized, comparative clinical trial. Eligible patients were randomly assigned to receive 150 mg of Tolperisone thrice daily or 8 mg of Thiocolchicoside twice daily for 7 days. PURPOSE: OVERVIEW OF LITERATURE: METHODS: The assessment of muscle spasm was made by measuring the finger-to-floor distance (FFD), articular excursion in degrees on performing Lasegue's maneuver and modified Schober's test. Assessment of pain on movement and spontaneous pain ( pain at rest) of the lumbar spine was made with the help of visual analogue scale score. RESULTS: The improvement in articular excursion on Lasegue's maneuver was significantly greater on day 3 (p = 0.017) and day 7 (p = 0.0001) with Tolperisone as compared to Thiocolchicoside. The reduction in FFD score was greater on day 7 (p = 0.0001) with Tolperisone. However there was no significant difference in improvement in Schober's test score on day 3 (p = 0.664) and day 7 (p = 0.192). The improvement in pain score at rest and on movement was significantly greater with Tolperisone ((p) = 0.0001). CONCLUSIONS:
Tolperisone is an effective and well tolerated option for treatment of patients with skeletal muscle spasm associated with pain.
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Authors | Rajeev Rao, Atul Panghate, Ajay Chandanwale, Indrajeet Sardar, Mriganka Ghosh, Modan Roy, Bireswar Banerjee, Ankur Goswami, Prakash P Kotwal |
Journal | Asian spine journal
(Asian Spine J)
Vol. 6
Issue 2
Pg. 115-22
(Jun 2012)
ISSN: 1976-7846 [Electronic] Korea (South) |
PMID | 22708015
(Publication Type: Journal Article)
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