Acute tubular necrosis due to cutaneous contact with cresol.

Abstract

The authors report a case of a 43-year-old woman who presented with second degree chemical burns to 9% of the total body surface area due to cutaneous contact with cresol. This was associated with acute oliguric kidney injury requiring haemodialysis. In contrast to previous reports of cresol ingestion, the patient did not have evidence of hepatic dysfunction, possibly due to a low cresol concentration in the portal vein and liver. Renal histopathology showed regional accentuated tubular necrosis and disruption of the tubular basement membrane. Renal toxicity was thought to be due to direct tubular toxicity and impaired renal blood flow.

• Authors: Koji Okamoto, Eisei Noiri, Machiko Oka, Hidekazu Moriya, Takayasu Ohtake, Shuzo Kobayashi
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2011 (Feb 24 2011) ISSN: 1757-790X [Electronic] England
• PMID: 22707573 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cresols
• cresol

Topics

• Adult
• Burns, Chemical (etiology)
• Cresols (toxicity)
• Female
• Humans
• Kidney Tubular Necrosis, Acute (chemically induced)
• Skin (injuries)