Cerium chloride improves protein and carbohydrate metabolism of fifth-instar larvae of Bombyx mori under phoxim toxicity.

Abstract

The organophosphorus pesticide poisoning of the silkworm Bombyx mori is one of the major events causing serious damage to sericulture. Added low-dose rare earths are demonstrated to increase resistance in animals. However, very little is known about whether or not added CeCl₃ can increase resistance of silkworm to phoxim poisoning. The present findings suggested that added CeCl₃ to mulberry leaves markedly increased contents of protein, glucose and pyruvate, and carbohydrate metabolism-related enzyme activities, including lactate dehydrogenase, succinate dehydrogenase and malate dehydrogenase, and attenuated free amino acids, urea, uric acid and lactate levels and inhibited the protein metabolism-related enzymes activities, such as protease, alanine aminotransferase and aspartate aminotransferase in the haemolymph of B. mori, under phoxim toxicity. These findings suggest that added CeCl₃ may improve protein and carbohydrate metabolisms, thus leading to increases of growth and survival rate of B. mori under phoxim stress.

• Authors: Bing Li, Yi Xie, Zhe Cheng, Jie Cheng, Rengping Hu, Xuezi Sang, Suxin Gui, Qingqing Sun, Xiaolan Gong, Yaling Cui, Weide Shen, Fashui Hong
• Journal: Biological trace element research (Biol Trace Elem Res) Vol. 150 Issue 1-3 Pg. 214-20 (Dec 2012) ISSN: 1559-0720 [Electronic] United States
• PMID: 22707218 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholinesterase Inhibitors
• Cholinesterase Reactivators
• Insect Proteins
• Insecticides
• Organothiophosphorus Compounds
• Cerium
• phoxim
• Lactate Dehydrogenases
• Malate Dehydrogenase
• Succinate Dehydrogenase
• Aspartate Aminotransferases
• Alanine Transaminase
• cerous chloride

Topics

• Alanine Transaminase (antagonists & inhibitors, metabolism)
• Animals
• Aspartate Aminotransferases (antagonists & inhibitors, metabolism)
• Bombyx (drug effects, growth & development, metabolism)
• Carbohydrate Metabolism (drug effects)
• Cerium (pharmacology)
• Cholinesterase Inhibitors (chemistry)
• Cholinesterase Reactivators (pharmacology)
• Crosses, Genetic
• Hemolymph (drug effects, enzymology, metabolism)
• Insect Proteins (agonists, antagonists & inhibitors, metabolism)
• Insecticide Resistance (drug effects)
• Insecticides (antagonists & inhibitors)
• Lactate Dehydrogenases (chemistry, metabolism)
• Larva (drug effects, growth & development, metabolism)
• Malate Dehydrogenase (chemistry, metabolism)
• Organothiophosphorus Compounds (antagonists & inhibitors)
• Protein Biosynthesis (drug effects)
• Proteolysis (drug effects)
• Succinate Dehydrogenase (chemistry, metabolism)