Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice.

Abstract

The purpose of the current study was to determine whether a tropical ginger derived compound 1'-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.

• Authors: Vinita Batra, Zanobia Syed, Jennifer N Gill, Malari A Coburn, Patrick Adegboyega, John DiGiovanni, J Michael Mathis, Runhua Shi, John L Clifford, Heather E Kleiner-Hancock
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 31 Pg. 57 (Jun 15 2012) ISSN: 1756-9966 [Electronic] England
• PMID: 22704648 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Benzyl Alcohols
• NF-kappa B
• Plant Extracts
• STAT3 Transcription Factor
• Stat3 protein, mouse
• Fluocinolone Acetonide
• 9,10-Dimethyl-1,2-benzanthracene
• Tetradecanoylphorbol Acetate
• 1'-acetoxychavicol acetate

Topics

• 9,10-Dimethyl-1,2-benzanthracene (toxicity)
• Alpinia (chemistry)
• Animals
• Benzyl Alcohols (pharmacology)
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Cell Transformation, Neoplastic (drug effects)
• Fluocinolone Acetonide (pharmacology)
• Ginger (chemistry)
• Humans
• Mice
• Mice, Transgenic
• NF-kappa B (antagonists & inhibitors, metabolism)
• Plant Extracts (chemistry, pharmacology)
• STAT3 Transcription Factor (genetics, metabolism)
• Skin Neoplasms (chemically induced, drug therapy, pathology)
• Tetradecanoylphorbol Acetate (pharmacology)