Abstract | PURPOSE: Although optimizing endogenous testosterone production before testicular sperm extraction is commonly practiced, whether improved preoperative testosterone levels enhance sperm retrieval remains unclear. We evaluated the influence of preoperative medical therapy in men with nonobstructive azoospermia before microdissection testicular sperm extraction. MATERIALS AND METHODS: RESULTS: Of the 736 men who had preoperative hormonal data 388 (53%) had baseline testosterone levels greater than 300 ng/dl. The sperm retrieval rate in these men was 56%. In the remaining 348 men with pretreatment testosterone levels less than 300 ng/dl, the sperm retrieval rate was similar (52%, p = 0.29). In addition, the sperm retrieval, clinical pregnancy and live birth rates were similar between men who responded to hormonal therapy and those who did not. CONCLUSIONS:
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Authors | Jennifer E Reifsnyder, Ranjith Ramasamy, Jad Husseini, Peter N Schlegel |
Journal | The Journal of urology
(J Urol)
Vol. 188
Issue 2
Pg. 532-6
(Aug 2012)
ISSN: 1527-3792 [Electronic] United States |
PMID | 22704105
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Aromatase Inhibitors
- Chorionic Gonadotropin
- Clomiphene
- Testosterone
|
Topics |
- Aromatase Inhibitors
(administration & dosage)
- Azoospermia
(blood, therapy)
- Chorionic Gonadotropin
(administration & dosage)
- Clomiphene
(administration & dosage)
- Female
- Follow-Up Studies
- Hormone Replacement Therapy
(methods)
- Humans
- Infant, Newborn
- Infertility, Male
(blood, therapy)
- Klinefelter Syndrome
(blood, therapy)
- Male
- Microdissection
(methods)
- Pregnancy
- Pregnancy Outcome
- Retrospective Studies
- Sperm Injections, Intracytoplasmic
- Sperm Retrieval
- Testosterone
(blood)
- Treatment Outcome
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