[Pharmacological effects of Abies polyprenols and carsil on alcohol-induced hepatitis].

Abstract

The introduction of polyprenols isolated from fir (Abies) tree in male rats weighing 170 - 180 g with alcohol-induced hepatitis favored reduction in hepatocyte cytolysis and cholestasis and led to an improvement of the protein- and glycogen-synthesizing function of liver. A clear tendency to normalization of the maintenance of total lipids, triglycerides and phospholipids and the inhibition of lipid peroxidization processes in the damaged organ was observed. The introduction of Abies polyprenols also improved the process of bile secretion and its chemical composition.

• Authors: E V Vaĭs, T V Khyrshkaĭnen, N V Tursunova, Z A Khushbaktova, V N Syrov, A V Kuchin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 4 Pg. 26-9 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 22702108 (Publication Type: Journal Article)

Chemical References

• Central Nervous System Depressants
• Silymarin
• Terpenes
• Ethanol
• Glycogen

Topics

• Abies (chemistry)
• Animals
• Bile (metabolism)
• Central Nervous System Depressants (adverse effects, pharmacology)
• Chemical and Drug Induced Liver Injury (drug therapy, metabolism)
• Ethanol (adverse effects, pharmacology)
• Glycogen (biosynthesis)
• Hepatocytes (metabolism)
• Lipid Peroxidation (drug effects)
• Male
• Protein Biosynthesis (drug effects)
• Rats
• Silymarin (chemistry)
• Terpenes (chemistry, pharmacology)