[Effect of human saliva on wound healing].

Abstract

OBJECTIVE:

To observe the effects of saliva on impaired raw surface so as to elucidate the possible mechanism in wound healing by comparing with Yunnan baiyao.

METHODS:

Six wounds (2.5 cm x 2.5 cm in size) were established at both sides on the back of 6 3-month-old adult Japanese rabbits (weighing 2.0-2.5 kg). According to treatment, 36 wounds were randomly divided into 3 groups: wounds were treated with 0.4 mL normal saline (blank control group, n = 12), 0.5 g Yunnan baiyao powder (Yunnan baiyao group, n = 12), and 0.4 mL saliva of health adult (saliva group, n = 12) for 15 days, respectively. And the general observation of raw surface, the scar formation time, wound healing rate, and histopathology were used to evaluate the effectiveness of saliva on wound healing.

RESULTS:

The wound healing speeds of saliva group and Yunnan baiyao group were faster than that of blank control group. The wound healing rates of saliva group were significantly higher than those of blank control group and Yunnan baiyao group at 5, 8, and 11 days after injury (P < 0.05). No obvious hemorrhage or necrosis of raw surfaces was observed in saliva group, and the raw surfaces generally were covered with epidermis at 15 days after injury. The inflammatory cells and microvessel density in saliva group were significantly less than those of Yunnan baiyao group and control group (P < 0.05).

CONCLUSION:

Saliva could obviously improve wound healing, which is related to its effects on reducing inflammatory cell infiltration, preventing wound infection, accelerating collagen fibers proliferation, and promoting vessel reconstruction in the process of wound healing.

• Authors: Jinjing Jia, Ying Sun, Huan Yang, Xinghui Wang, Lei Liu, Liang Zong, Hao Hu
• Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery (Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi) Vol. 26 Issue 5 Pg. 563-6 (May 2012) ISSN: 1002-1892 [Print] China
• PMID: 22702050 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• yunnan baiyao

Topics

• Animals
• Disease Models, Animal
• Drugs, Chinese Herbal (administration & dosage, pharmacology)
• Humans
• Male
• Rabbits
• Random Allocation
• Saliva
• Skin (drug effects, injuries)
• Time Factors
• Treatment Outcome
• Wound Healing (drug effects)
• Wound Infection (prevention & control)
• Wounds and Injuries (drug therapy)