Abstract | BACKGROUND:
Malignant melanoma is a deadly type of metastatic skin cancer with increased incidence over the past 30 years. Despite the advanced knowledge on the biology, immunobiology and molecular genetics of melanoma, the alternatives of treatment are limited with poor prognosis. On clinical trials, natural products and among them redox-active quinones have been tested in the attempt to control the growth of cancer cells. Recently, we isolated jacaranone from Pentacalia desiderabilis, a benzoquinone derivative that showed a broad antitumor activity and protective anti- melanoma effect in a syngeneic model. The purified substance is active at micromolar concentrations, is not hemolytic, and is not toxic in naïve mice. METHODOLOGY/PRINCIPAL FINDINGS: CONCLUSIONS/SIGNIFICANCE: The results provide evidence for the mechanisms of action of jacaranone and emphasize the potential use of this quinone for the treatment of melanoma.
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Authors | Mariana H Massaoka, Alisson L Matsuo, Carlos R Figueiredo, Camyla F Farias, Natália Girola, Denise C Arruda, Jorge A B Scutti, Paulete Romoff, Oriana A Favero, Marcelo J P Ferreira, João H G Lago, Luiz R Travassos |
Journal | PloS one
(PLoS One)
Vol. 7
Issue 6
Pg. e38698
( 2012)
ISSN: 1932-6203 [Electronic] United States |
PMID | 22701695
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Annexin A5
- Antineoplastic Agents
- Benzoquinones
- Chromatin
- Plant Extracts
- Reactive Oxygen Species
- Superoxides
- Propidium
- jacaranone
- Proto-Oncogene Proteins c-akt
- p38 Mitogen-Activated Protein Kinases
- Acetylcysteine
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Topics |
- Acetylcysteine
- Animals
- Annexin A5
- Antineoplastic Agents
(analysis, pharmacology, therapeutic use)
- Apoptosis
(drug effects)
- Asteraceae
(chemistry)
- Benzoquinones
(analysis, pharmacology, therapeutic use)
- Blotting, Western
- Cell Line, Tumor
- Chromatin
(metabolism)
- Colorimetry
- Down-Regulation
- Humans
- In Situ Nick-End Labeling
- In Vitro Techniques
- Male
- Melanoma
(drug therapy)
- Membrane Potential, Mitochondrial
- Mice
- Mice, Inbred C57BL
- Microscopy, Electron, Transmission
- Nuclear Magnetic Resonance, Biomolecular
- Phytotherapy
(methods)
- Plant Extracts
(pharmacology)
- Propidium
- Proto-Oncogene Proteins c-akt
(metabolism)
- Reactive Oxygen Species
(metabolism)
- Signal Transduction
(drug effects)
- Superoxides
- p38 Mitogen-Activated Protein Kinases
(metabolism)
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