HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The ferric aerobactin receptor IutA, a protein isolated on agarose column, is not essential for uropathogenic Escherichia coli infection.

Abstract
Although many proteins have been described involved in Escherichia coli colonization and infection, only few reports have shown lectins as important components in these processes. Because the mechanisms underlying E. coli colonization process involving lectins are not fully understood, we sought to identify the presence of other non-described lectins in E. coli. Here, we isolated a 75-kDa protein from E. coli on Sepharose column and identified it as ferric aerobactin receptor (IutA). Since IutA is controversially associated with virulence of some E. coli strains, mainly in uropathogenic E. coli (UPEC), we evaluated the presence of iutA gene in UPEC isolated from patients with urinary infection. This gene was present in only 38% of the isolates, suggesting a weak association with virulence. Because there is a redundancy in the siderophore-mediated uptake systems, we suggest that IutA can be advantageous but not essential for UPEC.
AuthorsTaise Natali Landgraf, Alan Berlese, Fabricio Freitas Fernandes, Mariani Lima Milanezi, Roberto Martinez, Ademilson Panunto-Castelo
JournalRevista latino-americana de enfermagem (Rev Lat Am Enfermagem) 2012 Mar-Apr Vol. 20 Issue 2 Pg. 340-5 ISSN: 1518-8345 [Electronic] Brazil
PMID22699735 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Bacterial Outer Membrane Proteins
  • aerobactin receptor
  • Sepharose
Topics
  • Bacterial Outer Membrane Proteins (isolation & purification, physiology)
  • Bacteriological Techniques (methods)
  • Escherichia coli Infections (microbiology)
  • Humans
  • Sepharose
  • Uropathogenic Escherichia coli (pathogenicity)
  • Virulence

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: