Effects of xylitol wipes on cariogenic bacteria and caries in young children.

The aim of the study was to investigate the efficacy of the use of xylitol-containing tooth-wipes in preventing dental caries in young children. In a double-blinded randomized controlled clinical trial, 44 mothers with active caries and their 6- to 35-month-old children were randomized to xylitol-wipe or placebo-wipe groups. The children's caries scores were recorded at baseline and 1 year. Salivary levels of mutans streptococci and lactobacilli were enumerated at baseline, 3, 6, and 12 months. Data were analyzed by intent-to-treat modeling with imputation for caries lesions and a linear mixed-effect model for bacterial levels. Significantly fewer children in the xylitol-wipe group had new caries lesions at 1 year compared with those in the placebo-wipe group (P < 0.05). No significant differences between the two groups were observed in levels of mutans streptococci and lactobacilli at all time-points. Daily xylitol-wipe application significantly reduced the caries incidence in young children as compared with wipes without xylitol, suggesting that the use of xylitol wipes may be a useful adjunct for caries control in infants (Clinicaltrials.gov registration number CT01468727).
AuthorsL Zhan, J Cheng, P Chang, M Ngo, P K Denbesten, C I Hoover, J D B Featherstone
JournalJournal of dental research (J Dent Res) Vol. 91 Issue 7 Suppl Pg. 85S-90S (Jul 2012) ISSN: 1544-0591 [Electronic] United States
PMID22699675 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Cariostatic Agents
  • Placebos
  • Sweetening Agents
  • Xylitol
  • Bacterial Load (drug effects)
  • Cariostatic Agents (administration & dosage, therapeutic use)
  • Child, Preschool
  • DMF Index
  • Dental Caries (microbiology, prevention & control)
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Lactobacillus (drug effects)
  • Male
  • Oral Hygiene
  • Placebos
  • Saliva (microbiology)
  • Streptococcus mutans (drug effects)
  • Sweetening Agents (administration & dosage, therapeutic use)
  • Xylitol (administration & dosage, therapeutic use)

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