A comparison of 0.1% timolol eye gel and 0.5% timolol eye drop in patients with chronic angle-closure glaucoma.

Abstract

BACKGROUND:

Primary angle-closure glaucoma has been reported with higher prevalence in Asian populations. There is no significant data of different response of topical medication between angle- closure and open angle eyes.

OBJECTIVE:

The present study investigates ocular hypotensive effect and systemic side effects of 0.1% timolol eye gel once daily compared with 0.5% timolol eye drop twice daily in patients with chronic angle-closure glaucoma.

MATERIAL AND METHOD:

The present study was a prospective, randomized, investigator-masked, two-period crossover study in chronic angle-closure glaucoma patients with each drug tested for a six-week period.

RESULTS:

Twenty five eyes were included. Timolol 0.1% eye gel and 0.5% timolol eye drop significantly reduced IOP at 9 am, 11 am and 3 pm compared with baseline (P < 0.001). At week 6, the mean IOP reduction from baseline of 0.5% timolol eye drop group was higher than that of 0.1% timolol eye gel group at 9 am (3.68 mmHg, 2.51 mmHg respectively) and at 11 am (4.21 mmHg, 2.51 mmHg respectively). These differences were not statistically significant (p = 0.421, p = 0.157 respectively). At 3 pm of week 6, the mean IOP change from baseline of 0.1% timolol eye gel group (3.03 mmHg) was more than that of 0.5% timolol eye drop group (2.84 mmHg). There was also statistically insignificant difference (p = 0.873). The highest IOP reduction of 0.5% timolol eye drop was 4.21 mmHg (19.82%) at 11 am of week 6 and that of 0.1% timolol eye gel was 3.03 mmHg (14.38%) at 3 pm of the same week. There was no significant ocular side effect. Systolic blood pressure after treatment with 0.1% timolol eye gel and diastolic blood pressure after treatment with 0.5% timolol eye drop were significantly decreased from baseline (P = 0.006 and P = 0.026 respectively). But there was no clinical significance.

CONCLUSION:

Timolol 0.5% eye drop and 0.1% timolol eye gel effectively reduced IOP in chronic angle-closure glaucoma patients. There was no statistically significant difference in the ocular hypotensive effect of both drugs over a 24-hour period. There was no ocular side effect. Systemic side effect was clinically insignificant difference in both groups.

• Authors: Ankana Metheetrairut, Panitee Leumsamran, Supamas Rojananin, Naris Kitnarong
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 95 Suppl 4 Pg. S116-22 (Apr 2012) ISSN: 0125-2208 [Print] Thailand
• PMID: 22696863 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antihypertensive Agents
• Gels
• Ophthalmic Solutions
• Timolol

Topics

• Adult
• Aged
• Antihypertensive Agents (administration & dosage)
• Cohort Studies
• Female
• Gels
• Glaucoma, Angle-Closure (drug therapy)
• Humans
• Male
• Middle Aged
• Ophthalmic Solutions
• Timolol (administration & dosage)
• Treatment Outcome