Abstract |
The aim of this study was to determine whether the tumor necrosis factor (TNF) promoter polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA). A meta-analysis was conducted on the A allele of the TNF -308 A/G and -238 A/G polymorphisms. The nine comparison studies including 1,132 JIA patients and 1,663 controls were included in the meta-analysis and consisted of 7 European, 1 Mexican, and 1 Turkish population. No association was found between JIA and the TNF -308 A allele and the TNF -238 A allele (odds ratio [OR] = 1.211, 95 % confidence interval [CI] = 0.917-1.598, P = 0.177; OR = 1.135, 95 % CI = 0.603-1.861, P = 0.615, respectively). Stratification by ethnicity did not show the association of the TNF -308 and -238 polymorphisms with JIA in Europeans. Mexicans were found to have lower prevalences of A alleles (2.9, 4.1 %) of the TNF -308 A/G and -238 A/G polymorphisms than any other population studied, and the Turkish population the highest (31.2, 26.9 %). This meta-analysis shows no association between the A alleles of the TNF -308 A/G or -238 A/G polymorphisms and JIA in Europeans, but that the prevalences of these alleles are ethnicity dependent.
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Authors | Young Ho Lee, Sang-Cheol Bae, Gwan Gyu Song |
Journal | Molecular biology reports
(Mol Biol Rep)
Vol. 39
Issue 8
Pg. 8497-503
(Aug 2012)
ISSN: 1573-4978 [Electronic] Netherlands |
PMID | 22696185
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tumor Necrosis Factor-alpha
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Topics |
- Alleles
- Arthritis, Juvenile
(genetics)
- Case-Control Studies
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Odds Ratio
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
- Tumor Necrosis Factor-alpha
(genetics)
- White People
(genetics)
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