New phenolic compounds from Dendrobium capillipes and Dendrobium secundum.

Abstract

Phytochemical investigation of the stem of Dendrobium capillipes resulted in the isolation of a new flavonol glycoside namely quercetin-3-O-α-L-rhamnopyranosyl-(1 → 2)-β-d-xylopyranoside, along with seven known phenolic compounds which included two flavonol glycosides and five bibenzyls. From the stem of Dendrobium secundum, a new compound named 5-hydroxy-3,4,3',4',5'-pentamethoxybibenzyl was characterized, together with two known bibenzyls and three glycosidic flavonoids. Some of the isolated bibenzyls showed cytotoxicity against KB, NCI-H187, and MCF-7 cancer cells, whereas all of the glycosidic flavonoids were devoid of activity.

• Authors: Thanawuth Phechrmeekha, Boonchoo Sritularak, Kittisak Likhitwitayawuid
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) Vol. 14 Issue 8 Pg. 748-54 ( 2012) ISSN: 1477-2213 [Electronic] England
• PMID: 22694103 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Bibenzyls
• Glycosides
• Phenols
• Quercetin

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Bibenzyls (chemistry, isolation & purification, pharmacology)
• Dendrobium (chemistry)
• Drug Screening Assays, Antitumor
• Female
• Glycosides (chemistry, isolation & purification, pharmacology)
• Humans
• KB Cells
• Molecular Structure
• Phenols (chemistry, isolation & purification, pharmacology)
• Quercetin (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Thailand