The effect of cellulose on crystal formation in the kidneys of guinea pigs fed diet rich in calcium and sodium.

Abstract

Our earlier report showed that diet rich in calcium and sodium fed to guinea pigs can be urolithogenic. In this study, we investigated the effect of adding 3% or 15% cellulose as a source of fiber into similar diet to asses the formation of kidney calculus. From the result, animals fed diet with 3% cellulose showed a relatively high concentration of urinary oxalate, urate and large number of crystals in the kidneys. When the cellulose level was raised to 15%, the concentrations of urinary calcium, urate and the number of crystals formed in the kidneys were lowered. We therefore, conclude that high fiber diet may be beneficial in reducing the incidence of kidney stones of calcium origin.

• Authors: S Syedhussain, K Tan, M Abu Bakar
• Journal: Malaysian journal of nutrition (Malays J Nutr) Vol. 2 Issue 1 Pg. 79-86 (Mar 1996) ISSN: 1394-035X [Print] Malaysia
• PMID: 22692100 (Publication Type: Journal Article)