Abstract |
7-hydroxy/oxo derivatives of dehydroepiandrosterone are potential regulators of the local cortisol activity due to their competition in the cortisolcortisone balance mediated by 11ß-hydroxysteroid dehydrogenase. 7-hydroxy-dehydroepiandrosterone is marketed as anti- obesity medication, though no clinical study aimed at the benefit of administering 7-oxygenated derivatives of dehydroepiandrosterone has appeared until now. We tried to show whether there exist differences in levels of circulating 7-hydroxy/oxo- dehydroepiandrosterone derivatives between lean and obese boys and girls. From a cohort of adolescents investigated within the frame of anti- obesity programme 10 obese boys and 10 obese girls were compared with age-matched lean boys and girls in their anthropometric data, and concentrations of both epimers of 7-hydroxy-dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone were determined by the RIA method. The basal levels of 7α-hydroxy-dehydroepiandrosterone were significantly higher in obese boys than in lean boys but not in girls. The association was found for anthropometric parameters and 7α-hydroxy-dehydroepiandrosterone, however again only in boys and not in girls. Higher levels of 7α-hydroxy-dehydroepiandrosterone its positive association with anthropometric data in obese boys may serve as a sign that, at least in boys, 7-oxygenated 5-ene-steroids may take part in regulating the hormonal signal for fat formation or distribution.
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Authors | B Sedláčková, L Dušátková, H Zamrazilová, P Matucha, M Bičíková, L Stárka |
Journal | Prague medical report
(Prague Med Rep)
Vol. 113
Issue 2
Pg. 147-55
( 2012)
ISSN: 1214-6994 [Print] Czech Republic |
PMID | 22691285
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 7-oxodehydroepiandrosterone
- Dehydroepiandrosterone
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Topics |
- Adolescent
- Body Size
- Dehydroepiandrosterone
(analogs & derivatives, blood)
- Female
- Humans
- Male
- Obesity
(blood)
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