The clinical effect of locally delivered minocycline in association with flap surgery for the treatment of chronic severe periodontitis: a split-mouth design.

Abstract

OBJECTIVE:

The purpose of this study was to determine the effectiveness of adjunctive application of locally delivered minocycline ointment associated with flap surgery for the treatment of patients with chronic severe periodontitis.

MATERIAL AND METHODS:

Twenty patients with chronic severe periodontitis were treated in a split-mouth study to either adjunctive application of locally delivered minocycline ointment in association with flap surgery (FM) or flap surgery only (FO); additional minocycline application was performed at 3 months post operation. Clinical evaluation of the plaque index, probing depth (PD), bleeding on probing (BOP), gingival recession, and clinical attachment level (CAL) was conducted at baseline and at 3 and 6 months after treatment.

RESULTS:

Clinical evaluations revealed that although both sites exhibited clinical improvement, there was a statistically significant reduction in PD (3.34 ± 0.03 mm) and BOP (78.01 ± 11.42%), and a significant gain of CAL (1.88 ± 0.21 mm) at the FM site compared with the FO site (reduction of PD and BOP: 2.62 ± 0.06 mm, 50.33 ± 15.01%, and gain of CAL: 1.55 ± 0.13 mm) at 6 months post operation (p < 0.05).

CONCLUSION:

Adjunctive application of locally delivered minocycline may be beneficial to the surgical treatment protocol of chronic severe periodontitis.

• Authors: Dong-Yeol Jung, Jung-Chul Park, Young-Taek Kim, Je-Young Yon, Gun-Il Im, Byung-Soo Kim, Seong-Ho Choi, Kyoo-Sung Cho, Chang-Sung Kim
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 39 Issue 8 Pg. 753-9 (Aug 2012) ISSN: 1600-051X [Electronic] United States
• PMID: 22691058 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 John Wiley & Sons A/S.

Chemical References

• Anti-Bacterial Agents
• Ointments
• Minocycline

Topics

• Administration, Topical
• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage)
• Chronic Periodontitis (drug therapy, surgery)
• Combined Modality Therapy
• Dental Plaque Index
• Female
• Follow-Up Studies
• Gingival Hemorrhage (drug therapy, surgery)
• Gingival Recession (drug therapy, surgery)
• Humans
• Male
• Middle Aged
• Minocycline (administration & dosage)
• Ointments
• Periodontal Attachment Loss (drug therapy, surgery)
• Periodontal Index
• Periodontal Pocket (drug therapy, surgery)
• Surgical Flaps
• Treatment Outcome