Studies on the constituents of Cimicifuga foetida collected in Guizhou Province and their cytotoxic activities.

Abstract

Two new triterpenoids and a chromone glycoside, namely, 24-epi-cimigenol-3-one (1), foetinoside (2), cimifugin-4'-O-[6″-feruloyl]-β-D-glucopyranoside (3), together with 18 known compounds, were isolated from the rhizomes of Cimicifuga foetida L. collected in Guizhou Province, China. All of the compounds were identified by spectroscopic methods, as well as chemical methods. In the in vitro cytotoxicity evaluation of these compounds against 5 human cancer cell lines, cimigenol (8) exerted the most potent cytotoxic activity against SMMC-7721 (7.87 µM) and A-549 (12.16 µM), while cimiacerin B (9) also showed obvious cytotoxicity against the A-549 cell line, with an IC(50) value of 16.77 µM.

• Authors: Lu Lu, Jian-Chao Chen, Yan Li, Chen Qing, Yuan-Yuan Wang, Yin Nian, Ming-Hua Qiu
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 60 Issue 5 Pg. 571-7 ( 2012) ISSN: 1347-5223 [Electronic] Japan
• PMID: 22689393 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 24-epi-cimigenol-3-one
• Chromones
• Glycosides
• Triterpenes
• cimifugin-4'-O-(6''-feruloyl)-beta-D-glucopyranoside
• foetinoside

Topics

• Apoptosis (drug effects)
• Cell Line, Tumor
• Chromones (chemistry, isolation & purification, toxicity)
• Cimicifuga (chemistry)
• Drug Screening Assays, Antitumor
• Glycosides (chemistry, isolation & purification, toxicity)
• Humans
• Magnetic Resonance Spectroscopy
• Molecular Conformation
• Rhizome (chemistry)
• Triterpenes (chemistry, isolation & purification, toxicity)