[Possible mechanisms of anti-ulcer action of silatranes].

Abstract

A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.

• Authors: M M Rasulov, I G Kuznetsov, S K Suslova, M V Velikaia, M G Voronkov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 110 Issue 9 Pg. 249-52 (Sep 1990) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: K voprosu o vozmozhnykh mekhanizmakh ul'tserostaticheskogo deĭstviia silatranov.
• PMID: 2268706 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Bridged Bicyclo Compounds
• Bridged Bicyclo Compounds, Heterocyclic
• Drug Combinations
• Ferric Compounds
• Organosilicon Compounds
• silatrane
• 2,3-Diketogulonic Acid
• oxyferriscorbone
• Uracil
• 6-methyluracil
• Alloxan
• 1-(chloromethyl)silatrane
• Silicon

Topics

• 2,3-Diketogulonic Acid (pharmacology, therapeutic use)
• Alloxan (pharmacology, therapeutic use)
• Animals
• Anti-Ulcer Agents (therapeutic use)
• Bridged Bicyclo Compounds (pharmacology, therapeutic use)
• Bridged Bicyclo Compounds, Heterocyclic
• Drug Combinations
• Ferric Compounds (pharmacology, therapeutic use)
• Lipid Peroxidation (drug effects)
• Organosilicon Compounds
• Rats
• Silicon (pharmacology, therapeutic use)
• Stomach Ulcer (drug therapy)
• Uracil (analogs & derivatives, pharmacology, therapeutic use)