Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format.

Abstract

We describe a method that enables specific and efficient conjugation of hydrazide-moieties to an IgG targeting the tumor neovasculature. The resulting chemically defined, homogeneous hydrazone-linked IgG conjugates remain immunoreactive and have a half-life of approximately 18 hours at physiological pH and temperature suitable for localized delivery of toxic drugs.

• Authors: Kathrin Zuberbühler, Giulio Casi, Gonçalo J L Bernardes, Dario Neri
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 48 Issue 56 Pg. 7100-2 (Jul 18 2012) ISSN: 1364-548X [Electronic] England
• PMID: 22684082 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Hydrazines
• Immunoglobulin G
• Oligosaccharides
• Fucose

Topics

• Antibodies, Monoclonal (chemistry, immunology)
• Fucose (chemistry, immunology)
• Hydrazines (chemistry, immunology)
• Hydrogen-Ion Concentration
• Immunoglobulin G (chemistry, immunology)
• Molecular Structure
• Oligosaccharides (chemistry, immunology)
• Temperature