Abstract |
It has been reported that treatment with tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection significantly suppressed both infectious virus production and HCMV replication in the human embryonic fibroblast cell line MRC-5. In this paper, we examined the mechanisms for the anti-HCMV effects of tricin in MRC-5 cells. Exposure of fibroblasts to tricin inhibited infectious HCMV production, with concomitant decreases in levels of transcripts of the CXC chemokine IFN-inducible T cell alpha chemoattractant (I-TAC or CXCL11) gene. We also found that the transcripts of the HCMV immediate early (IE) gene and replication of HCMV were lower in CXCL11 gene-knockdown cells. These results suggest that tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. In addition, it is possible that CXCL11 is the one of the targets of tricin.
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Authors | Tsugiya Murayama, Ying Li, Takashi Takahashi, Rie Yamada, Keiko Matsubara, Yuuzo Tuchida, Zhuan Li, Hidetaka Sadanari |
Journal | Microbes and infection
(Microbes Infect)
Vol. 14
Issue 12
Pg. 1086-92
(Oct 2012)
ISSN: 1769-714X [Electronic] France |
PMID | 22683667
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Institut Pasteur. All rights reserved. |
Chemical References |
- Antiviral Agents
- CXCL11 protein, human
- Chemokine CXCL11
- Flavonoids
- Plant Extracts
- tricin
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Topics |
- Antiviral Agents
(isolation & purification, pharmacology)
- Cell Line
- Chemokine CXCL11
(genetics, metabolism)
- Cytomegalovirus
(drug effects, physiology)
- Fibroblasts
(drug effects, virology)
- Flavonoids
(isolation & purification, pharmacology)
- Gene Expression
(drug effects)
- Gene Expression Profiling
- Gene Knockout Techniques
- Humans
- Plant Extracts
(isolation & purification, pharmacology)
- Sasa
(chemistry)
- Virus Replication
(drug effects)
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