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Anti-cytomegalovirus effects of tricin are dependent on CXCL11.

Abstract
It has been reported that treatment with tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection significantly suppressed both infectious virus production and HCMV replication in the human embryonic fibroblast cell line MRC-5. In this paper, we examined the mechanisms for the anti-HCMV effects of tricin in MRC-5 cells. Exposure of fibroblasts to tricin inhibited infectious HCMV production, with concomitant decreases in levels of transcripts of the CXC chemokine IFN-inducible T cell alpha chemoattractant (I-TAC or CXCL11) gene. We also found that the transcripts of the HCMV immediate early (IE) gene and replication of HCMV were lower in CXCL11 gene-knockdown cells. These results suggest that tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. In addition, it is possible that CXCL11 is the one of the targets of tricin.
AuthorsTsugiya Murayama, Ying Li, Takashi Takahashi, Rie Yamada, Keiko Matsubara, Yuuzo Tuchida, Zhuan Li, Hidetaka Sadanari
JournalMicrobes and infection (Microbes Infect) Vol. 14 Issue 12 Pg. 1086-92 (Oct 2012) ISSN: 1769-714X [Electronic] France
PMID22683667 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Institut Pasteur. All rights reserved.
Chemical References
  • Antiviral Agents
  • CXCL11 protein, human
  • Chemokine CXCL11
  • Flavonoids
  • Plant Extracts
  • tricin
Topics
  • Antiviral Agents (isolation & purification, pharmacology)
  • Cell Line
  • Chemokine CXCL11 (genetics, metabolism)
  • Cytomegalovirus (drug effects, physiology)
  • Fibroblasts (drug effects, virology)
  • Flavonoids (isolation & purification, pharmacology)
  • Gene Expression (drug effects)
  • Gene Expression Profiling
  • Gene Knockout Techniques
  • Humans
  • Plant Extracts (isolation & purification, pharmacology)
  • Sasa (chemistry)
  • Virus Replication (drug effects)

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