Conditioned food aversion reconsolidation in snails is impaired by translation inhibitors but not by transcription inhibitors.

Abstract

Memory is destabilized during retrieval-induced reconsolidation and can therefore be disrupted or modified. In the present study, we examined the role of translation and transcription processes in long-term food aversion memory reconsolidation in the snail Helix lucorum. The administration of the protein synthesis inhibitor anisomycin followed by a reminding procedure (presentation of the conditioned stimulus) led to the development of amnesia that persist for 2 weeks or longer. Administration of the mRNA synthesis inhibitors actinomycin D, α-amanitin, or DRB (5,6-dichloro-1-β-D-ribofuranosylbenzimidasole) followed by a reminding procedure did not affect memory retrieval. Our present findings indicate that proteins synthesized from preexisting mRNA that is transcribed during learning and stored in a silent state may be involved in the mechanisms of conditioned food aversion reconsolidation.

• Authors: Svetlana Solntseva, Vladimir Nikitin
• Journal: Brain research (Brain Res) Vol. 1467 Pg. 42-7 (Jul 27 2012) ISSN: 1872-6240 [Electronic] Netherlands
• PMID: 22683361 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Alpha-Amanitin
• Nucleic Acid Synthesis Inhibitors
• Protein Synthesis Inhibitors
• RNA, Messenger
• Dactinomycin
• Dichlororibofuranosylbenzimidazole
• Anisomycin

Topics

• Alpha-Amanitin (pharmacology)
• Animals
• Anisomycin (pharmacology)
• Avoidance Learning (drug effects)
• Dactinomycin (pharmacology)
• Data Interpretation, Statistical
• Dichlororibofuranosylbenzimidazole (pharmacology)
• Food
• Nucleic Acid Synthesis Inhibitors (pharmacology)
• Protein Biosynthesis (drug effects)
• Protein Synthesis Inhibitors (pharmacology)
• RNA, Messenger (biosynthesis)
• Snails (physiology)
• Transcription, Genetic (drug effects)