Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.

Abstract

In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.

• Authors: Ye Wang, Xiao-Yuan Zi, Juan Su, Hong-Xia Zhang, Xin-Rong Zhang, Hai-Ying Zhu, Jian-Xiu Li, Meng Yin, Feng Yang, Yi-Ping Hu
• Journal: International journal of nanomedicine (Int J Nanomedicine) Vol. 7 Pg. 2641-52 ( 2012) ISSN: 1178-2013 [Electronic] New Zealand
• PMID: 22679374 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Copper
• cuprous oxide
• Dithiothreitol

Topics

• Animals
• Apoptosis (drug effects)
• Cell Cycle Checkpoints (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Copper (chemistry, pharmacology, toxicity)
• Dithiothreitol (pharmacology)
• Fibroblasts (drug effects)
• Flow Cytometry
• HeLa Cells
• Humans
• Lipid Peroxidation (drug effects)
• Metal Nanoparticles (administration & dosage, chemistry, toxicity)
• Mice
• Mice, Inbred C57BL
• Microscopy, Electron, Transmission
• Toxicity Tests