Should we be analysing breast reduction specimens? A systematic analysis of over 1,000 consecutive cases.

Abstract

BACKGROUND:

Reduction mammoplasty (RM) continues to be popular. The reported incidence of occult breast carcinoma in these specimens varies between 0.05 and 1.8 %. Literature review reveals a wide discrepancy in study methodology, outcome measures, and even what is constituted as a "significant" result. We set out to identify RM patients at increased risk of occult significant pathological findings to engender a systematic improvement in efficiency of those specimens sent for histopathological examination.

METHODS:

A single-centre retrospective study of the pathology results for 1,388 consecutive RM patients was undertaken. Patients were divided into three groups according to indication for surgery: group 1, macromastia; group 2, developmental asymmetry; and group 3, symmetrising surgery after breast cancer reconstructive surgery.

RESULTS:

Nine cases of occult carcinoma were found among the 1,388 women (0.65 %), all in patients over 35 years of age. Forty percent of all patients were under 35 years old. Histopathological analysis of 59 % of patients revealed nonsignificant findings. Patients with a breast cancer history were 4.3 times more likely to have occult breast cancer. Patients under 30 years of age had a significantly higher chance of nonsignificant findings than those over 30 (relative risk = 2.5).

CONCLUSIONS:

Although the overall incidence of occult breast cancer in reduction mammaplasty patients remains low, specific subgroups with a higher risk are identified. It is recommended that histological analysis of specimens should be restricted to high-risk patients and those over 30 years of age as significant pathology is uncommon in younger patients. These results will promote health-care-related economic benefits and a reduction of the burden placed on histopathology departments.

LEVEL OF EVIDENCE IV:

This journal requires that authors assign a level of evidence to each article.

• Authors: Faiza E Hassan, Marc D Pacifico
• Journal: Aesthetic plastic surgery (Aesthetic Plast Surg) Vol. 36 Issue 5 Pg. 1105-13 (Oct 2012) ISSN: 1432-5241 [Electronic] United States
• PMID: 22678135 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Breast (pathology, surgery)
• Breast Neoplasms (pathology)
• Female
• Humans
• Incidental Findings
• Mammaplasty
• Middle Aged
• Retrospective Studies
• Young Adult