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Dietary inorganic phosphorus regulates the intestinal peptide transporter PepT1.

AbstractBACKGROUND:
Both organic and inorganic phosphorus (Pi) are present in regularly consumed foods, such as meats, eggs, and dairy products. Pi is often included in foods as an additive (as hidden phosphorus). The intestinal peptide transporter PepT1 mediates protein absorption, which is disturbed in renal insufficiency. Our aim was to determine the effects of dietary Pi content on the peptide transport activity and expression of PepT1.
METHODS:
The following animal models were used: (1) 7-week-old male Wistar rats; and (2) rats that underwent 3/4 nephrectomy to induce chronic kidney disease (CKD). The rats were fed a normal-protein (20%) diet containing low (0.02%), normal (0.6%), or high (1.2%) Pi levels. They were also fed diets containing varying amounts of protein and either low or normal Pi levels as follows: (1) low Pi/normal protein, (2) low Pi/high (50%) protein, (3) normal Pi/normal protein, and (4) normal Pi/high protein.
RESULTS:
Intestinal peptide transport activity and PepT1 expression levels were significantly higher in the CKD rats than in sham-operated control ones. Compared with the normal-protein diet, the high-protein diet increased PepT1 expression in the CKD rats. Intestinal dipeptide transport activity and PepT1 protein levels did not increase in the rats fed the low-Pi/high-protein diet. In contrast, intestinal dipeptide transport activity and PepT1 protein expression were markedly increased in the rats fed the normal-Pi/high-protein diet.
CONCLUSION:
Dietary Pi levels regulate intestinal peptide transport activity through PepT1.
AuthorsJunya Furutani, Hiroko Segawa, Fumito Aranami, Shoji Kuwahara, Mikio Sugano, Kenji Bannai, Hideyuki Yamato, Mikiko Ito, Ken-ichi Miyamoto
JournalJournal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation (J Ren Nutr) Vol. 23 Issue 2 Pg. e11-20 (Mar 2013) ISSN: 1532-8503 [Electronic] United States
PMID22677630 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Peptide Transporter 1
  • Phosphorus, Dietary
  • Slc15a1 protein, rat
  • Symporters
Topics
  • Animals
  • Biological Transport (drug effects)
  • Chronic Disease
  • Diet
  • Gene Expression Regulation
  • Intestinal Absorption (drug effects)
  • Intestinal Mucosa (metabolism)
  • Intestines (drug effects)
  • Kidney (drug effects, pathology)
  • Male
  • Nephrectomy (methods)
  • Peptide Transporter 1
  • Phosphorus, Dietary (administration & dosage, pharmacokinetics)
  • Rats
  • Rats, Wistar
  • Renal Insufficiency (drug therapy, pathology)
  • Symporters (genetics, metabolism)

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