Abstract | BACKGROUND: Both organic and inorganic phosphorus (Pi) are present in regularly consumed foods, such as meats, eggs, and dairy products. Pi is often included in foods as an additive (as hidden phosphorus). The intestinal peptide transporter PepT1 mediates protein absorption, which is disturbed in renal insufficiency. Our aim was to determine the effects of dietary Pi content on the peptide transport activity and expression of PepT1. METHODS: The following animal models were used: (1) 7-week-old male Wistar rats; and (2) rats that underwent 3/4 nephrectomy to induce chronic kidney disease (CKD). The rats were fed a normal- protein (20%) diet containing low (0.02%), normal (0.6%), or high (1.2%) Pi levels. They were also fed diets containing varying amounts of protein and either low or normal Pi levels as follows: (1) low Pi/normal protein, (2) low Pi/high (50%) protein, (3) normal Pi/normal protein, and (4) normal Pi/high protein. RESULTS: CONCLUSION: Dietary Pi levels regulate intestinal peptide transport activity through PepT1.
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Authors | Junya Furutani, Hiroko Segawa, Fumito Aranami, Shoji Kuwahara, Mikio Sugano, Kenji Bannai, Hideyuki Yamato, Mikiko Ito, Ken-ichi Miyamoto |
Journal | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
(J Ren Nutr)
Vol. 23
Issue 2
Pg. e11-20
(Mar 2013)
ISSN: 1532-8503 [Electronic] United States |
PMID | 22677630
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Peptide Transporter 1
- Phosphorus, Dietary
- Slc15a1 protein, rat
- Symporters
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Topics |
- Animals
- Biological Transport
(drug effects)
- Chronic Disease
- Diet
- Gene Expression Regulation
- Intestinal Absorption
(drug effects)
- Intestinal Mucosa
(metabolism)
- Intestines
(drug effects)
- Kidney
(drug effects, pathology)
- Male
- Nephrectomy
(methods)
- Peptide Transporter 1
- Phosphorus, Dietary
(administration & dosage, pharmacokinetics)
- Rats
- Rats, Wistar
- Renal Insufficiency
(drug therapy, pathology)
- Symporters
(genetics, metabolism)
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