FET-PET assessed recurrence pattern after radio-chemotherapy in newly diagnosed patients with glioblastoma is influenced by MGMT methylation status.

Abstract

BACKGROUND AND PURPOSE:

The aim of the present study was to evaluate factors predicting the recurrence pattern determined by [(18)F]FET-PET imaging in patients with newly diagnosed glioblastoma after combined radio-chemotherapy treated according to the EORTC/NCIC trial.

MATERIAL AND METHODS:

Seventy-nine patients with newly diagnosed GBM treated with radiotherapy plus temozolomide (75 mg/m(2)/d) followed by adjuvant cyclic (5/28 days) temozolomide (150-200 mg/m(2)) were retrospectively analysed. Recurrence patterns were assessed by means of positron-emission-tomography with [(18)F]FET and additional MRI; in 54 patients MGMT methylation status was evaluated.

RESULTS:

Whilst 49.4% of the patients had an in-field recurrence, 12.6% an ex-field recurrence and 3.8% a recurrence at the field margin, 34.2% of the patients did not relapse during follow-up (median 595 days). Considering all patients included in this study, 41.5% (12/29) of the MGMT methylated population had no relapse, 37.9% (11/29) had an in-field-recurrence and 20.7% (6/29) an ex-field/marginal recurrence, whilst 28.0% (7/25) of the MGMT unmethylated population had no relapse, 64.0% (16/25) had an in-field-recurrence and 8.0% (2/25) an ex-field/marginal recurrence (p=0.15).

CONCLUSIONS:

After the administration of temozolomide concomitant with and adjuvant to radiotherapy in patients with glioblastoma, the pattern determined by [(18)F]FET-PET seems to be associated with MGMT methylation status.

• Authors: Maximilian Niyazi, Oliver Schnell, Bogdana Suchorska, Silke Birgit Schwarz, Ute Ganswindt, Julia Geisler, Peter Bartenstein, Friedrich-Wilhelm Kreth, Jörg-Christian Tonn, Sabina Eigenbrod, Claus Belka, Christian la Fougère
• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 104 Issue 1 Pg. 78-82 (Jul 2012) ISSN: 1879-0887 [Electronic] Ireland
• PMID: 22673727 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Tumor Suppressor Proteins
• (18F)fluoroethyltyrosine
• Tyrosine
• DNA Modification Methylases
• MGMT protein, human
• DNA Repair Enzymes

Topics

• Adult
• Aged
• Aged, 80 and over
• Brain Neoplasms (genetics, mortality, therapy)
• Chemoradiotherapy
• DNA Methylation
• DNA Modification Methylases (genetics)
• DNA Repair Enzymes (genetics)
• Female
• Glioblastoma (genetics, mortality, therapy)
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnostic imaging)
• Positron-Emission Tomography
• Tumor Suppressor Proteins (genetics)
• Tyrosine (analogs & derivatives)