HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A₂ activity.

Abstract
Tocopheryl succinates (TOSs) are, in contrast to tocopherols, highly cytotoxic against many cancer cells. In this study the enzyme activity of secretory phospholipase A(2) towards various succinate-phospholipid conjugates has been investigated. The synthesis of six novel phospholipids is described, including two TOS phospholipids conjugates. The studies revealed that the TOS conjugates are poor substrates for the enzyme whereas the phospholipids with alkyl and phenyl succinate moieties were hydrolyzed by the enzyme to a high extent.
AuthorsPalle J Pedersen, Hélène M-F Viart, Fredrik Melander, Thomas L Andresen, Robert Madsen, Mads H Clausen
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 20 Issue 13 Pg. 3972-8 (Jul 01 2012) ISSN: 1464-3391 [Electronic] England
PMID22672983 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Phospholipids
  • Succinic Acid
  • Phospholipases A2
  • Tocopherols
Topics
  • Cell Line, Tumor
  • Humans
  • Phospholipases A2 (metabolism)
  • Phospholipids (chemistry)
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Substrate Specificity
  • Succinic Acid (chemistry)
  • Tocopherols (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: