Abstract | INTRODUCTION: AIMS: To determine the clinical effectiveness of the antispasmodic agents available in Mexico for the treatment of IBS. METHODS: We carried out a systematic review and meta-analysis of randomized controlled clinical trials on antispasmodic agents for IBS treatment. Clinical trials identified from January 1960 to May 2011 were searched for in MEDLINE, the Cochrane Library, and in the ClinicalTrials.gov registry. Treatment response was evaluated by global improvement of symptoms or abdominal pain, abdominal distention/bloating, and frequency of adverse events. The effect of antispasmodics vs placebo was expressed in OR and 95% CI. RESULTS: Twenty-seven studies were identified, 23 of which fulfilled inclusion criteria. The studied agents were pinaverium bromide, mebeverine, otilonium, trimebutine, alverine, hyoscine, alverine/ simethicone, pinaverium/ simethicone, fenoverine, and dicyclomine. A total of 2585 patients were included in the meta-analysis. Global improvement was 1.55 (CI 95%: 1.33 to 1.83). Otilonium and the alverine/ simethicone combination produced significant values in global improvement while the pinaverium/ simethicone combination showed improvement in bloating. As for pain, 2394 patients were included with an OR of 1.52 (IC 95%: 1.28 a 1.80), favoring antispasmodics. CONCLUSIONS:
|
Authors | M A Martínez-Vázquez, G Vázquez-Elizondo, J A González-González, R Gutiérrez-Udave, H J Maldonado-Garza, F J Bosques-Padilla |
Journal | Revista de gastroenterologia de Mexico
(Rev Gastroenterol Mex)
2012 Apr-Jun
Vol. 77
Issue 2
Pg. 82-90
ISSN: 0375-0906 [Print] Mexico |
PMID | 22672854
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
|
Copyright | Copyright © 2011 Asociación Mexicana de Gastroenterología. Published by Elsevier España. All rights reserved. |
Chemical References |
|
Topics |
- Drug Therapy, Combination
- Humans
- Irritable Bowel Syndrome
(diagnosis, drug therapy)
- Parasympatholytics
(adverse effects, therapeutic use)
- Randomized Controlled Trials as Topic
|