Detection of cranial meningiomas: comparison of ⁶⁸Ga-DOTATOC PET/CT and contrast-enhanced MRI.

PET imaging with somatostatin receptor ligands, such as (68)Ga-DOTATOC, is a well-established method for detection and target volume definition of meningiomas prior to radiotherapy. Since DOTATOC PET delivers a higher contrast between meningiomas and surrounding tissues than MRI, we conducted a retrospective analysis to compare the diagnostic accuracy of contrast-enhanced MRI (CE-MRI) with (68)Ga-DOTATOC PET/CT in patients with cranial meningiomas prior to radiotherapy.
Over a period of 6 years, 134 patients (20-82 years of age, 107 women and 27 men) underwent cranial CE-MRI and (68)Ga-DOTATOC PET/CT. To compare the two methods, the lesions considered typical of meningiomas visually were counted and analysed with respect to their location and SUVmax.
In the 134 patients investigated by both modalities, 190 meningiomas were detected by (68)Ga-DOTATOC PET/CT and 171 by CE-MRI. With knowledge of the PET/CT data, the MRI scans were reinvestigated, which led to the detection of 4 of the 19 incidental meningiomas, resulting in an overall detection rate of 92 % of the meningioma lesions that were found by PET/CT.
Ga-DOTATOC PET/CT demonstrated an improved sensitivity in meningioma detection when compared to CE-MRI. Tumours adjacent to the falx cerebri, located at the skull base or obscured by imaging artefacts or calcification are particularly difficult to detect by MRI. Therefore (68)Ga-DOTATOC PET/CT may provide additional information in patients with uncertain or equivocal results on MRI or could help to confirm a diagnosis of meningioma based on MRI or could help to confirm MRI-based diagnosis of meningiomas in cases of biopsy limitations. It is possible that not only radiotherapy and surgical planning, but also follow-up strategies would benefit from this imaging modality.
AuthorsAli Afshar-Oromieh, Frederik L Giesel, Heinz G Linhart, Uwe Haberkorn, Sabine Haufe, Stephanie E Combs, Dino Podlesek, Michael Eisenhut, Clemens Kratochwil
JournalEuropean journal of nuclear medicine and molecular imaging (Eur J Nucl Med Mol Imaging) Vol. 39 Issue 9 Pg. 1409-15 (Sep 2012) ISSN: 1619-7089 [Electronic] Germany
PMID22669255 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Contrast Media
  • Organometallic Compounds
  • Octreotide
  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Neoplasms (diagnosis, radionuclide imaging, radiotherapy)
  • Contrast Media
  • Female
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Male
  • Meningeal Neoplasms (diagnosis, radionuclide imaging, radiotherapy)
  • Meningioma (diagnosis, radionuclide imaging, radiotherapy)
  • Middle Aged
  • Multimodal Imaging (methods)
  • Octreotide (analogs & derivatives)
  • Organometallic Compounds
  • Positron-Emission Tomography
  • Retrospective Studies
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed
  • Young Adult

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