Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells.

Abstract

A new class of hybrid chalcones (17a-l &18a-l) was synthesized by Claisen-Schmidt condensation. All compounds were characterized by (1)H NMR, IR and mass spectral analysis and tested for their cytotoxic activity against PC-3 (prostate cancer), HT-29 (colon cancer), B-16 (mouse macrophages) and NCI-H460 (lung cancer) cell lines. Three compounds 18i, 18j and 18l (IC(50)=8.4, 7.9 & 5.9 μM) showed significant activity against PC-3 cell line.

• Authors: M Nagaraju, E Gnana Deepthi, C Ashwini, M V P S Vishnuvardhan, V Lakshma Nayak, Rajesh Chandra, S Ramakrishna, B B Gawali
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 22 Issue 13 Pg. 4314-7 (Jul 01 2012) ISSN: 1464-3405 [Electronic] England
• PMID: 22668451 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Chalcone

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, therapeutic use, toxicity)
• Apoptosis (drug effects)
• Cell Line, Tumor
• Chalcone (analogs & derivatives, therapeutic use, toxicity)
• Drug Screening Assays, Antitumor
• Humans
• Male
• Mice
• Prostatic Neoplasms (drug therapy)
• Structure-Activity Relationship